Introduction

CNMamide was recently discovered following a search of the Drosophila melanogaster genome (Jung et al., 2014). CNMamide is an arthropod-specific peptide and has a conserved Cys-Asp-Met-amide C-terminus. It contains two cysteine residues, which suggests that the peptide becomes cyclized by a disulfide bridge. Drosophila CNMamide binds to and activates the orphan GPCR, CG33696. Other insects may possess two CNMamide receptors; however, these have not yet been deorphanized.

Location

CNMamide is expressed in several neurons in the brain and ventral nerve cord of D. melanogaster. Knockdown of CNMa in D. melanogaster increases the latency to sperm ejection by females after copulation (Lee et al., 2015).

Function

Information not available

SeqLogo and Cladogram

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Suggested Reviews

References

• Jung, S.H., Lee, J.H., Chae, H.S., Seong, J.Y., Park, Y., Park, Z.Y., Kim, Y.J., 2014. Identification of a novel insect neuropeptide, CNMa and its receptor. FEBS Lett. 588, 2037–2041. doi:10.1016/j.febslet.2014.04.028
• Lee, K.-M., Daubnerová, I., Isaac, R.E., Zhang, C., Choi, S., Chung, J., Kim, Y.-J., 2015. A Neuronal Pathway that Controls Sperm Ejection and Storage in Female Drosophila. Curr. Biol. 25, 790–797. doi:10.1016/j.cub.2015.01.050