nEUROSTRESSPEP logo

DINeR

A Database for Insect Neuropeptide Research

Search the database for information about the various species and neuropeptides of interest

Insect Neuropeptides - Natalisin

Introduction

The neuropeptide natalisin and its receptor, were first identified and characterized in three different insects: Drosophila melanogaster, Tribolium castaneum, and Bombyx mori (Jiang et al., 2013). The C-terminus of natalisin (FX1PX2Ramide, or FX1X2X3Ramide) bears some similarities to tachykinin-related peptides (TRPs) of invertebrates (FXGXRamide). The Drosophila natalisin receptor (CG6515) was previously known as NKD or TakR86C and considered a receptor for tachykinin-related peptide 6 (DTK6) which has the C-terminal sequence FVAVRamide and thus activate CG6515 at higher concentrations. There are 5 natalisins encoded by the precursor (CG34388) in Drosophila, 2 in Tribolium, and 11 in Bombyx mori. The natalisin ligand and receptor appear to be ancestrally related to the TRP/TRP receptor system. Natalisin and its receptor seem to be lacking in the honey bee A. mellifera and the wasp Nasonia vitripennis (Jiang et al., 2016).

Location

In the three holometabolus insects investigated, natalisin expression was found in 3–4 pairs of interneurons in the brain (possibly a few neurosecretory cells in pars intercerebralis?).

Function

Genetic knockdown of the natalisin signaling components leads to defects in reproductive behavior of male and female Drosophila and natalisin-RNAi injections reduce fecundity in Tribolium. The name natalisin is derived from the Latin word natalis, birth, to reflect it’s role in reproduction.

SeqLogo and Cladogram

Click above image to go to SeqLogo and Cladogram page

References

  • Jiang H, Lkhagva A, Daubnerova I, Chae HS, Simo L, Jung SH, Yoon YK, Lee NR, Seong JY, Zitnan D, Park Y, Kim YJ. 2013. Natalisin, a tachykinin-like signaling system, regulates sexual activity and fecundity in insects. Proc Natl Acad Sci U S A 110(37):E3526-3534.
  • Jiang H, Kim D, Dobesh S, Evans JD, Nachman RJ, Kaczmarek K, Zabrocki J, Park Y. 2016. Ligand selectivity in tachykinin and natalisin neuropeptidergic systems of the honey bee parasitic mite Varroa destructor. Sci Rep 6:19547.